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2-Hydroxybenzylamine

Catalog No. T41358 CAS 932-30-9

2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial arrhythmias following atrial fibrillation ablation by decreasing IsoLG adducts with native biomolecules.

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2-Hydroxybenzylamine, CAS 932-30-9

Pack Size	Availability	Price/USD
500 mg	In stock	$ 57.00
1 g	In stock	$ 91.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98.59%

Biological Description

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Description

In vivo

Compared to hypercholesterolemic Ldlr-/- mice treated with vehicle or 4-Hydroxybenzylamine, a nonreactive analogue, 2-Hydroxybenzylamine decreases atherosclerosis by 60% in en face aortas, without changing plasma cholesterol. Ldlr-/- mice treated with 2-Hydroxybenzylamine have reduced MDA-LDL and MDA-HDL levels, and their HDL display increased capacity to reduce macrophage cholesterol. Importantly, 2-Hydroxybenzylamine reduces the MDA- and IsoLG-lysyl content in atherosclerotic aortas versus 4-Hydroxybenzylamine. Furthermore, 2-Hydroxybenzylamine reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. Dicarbonyl scavenging with 2-Hydroxybenzylamine has multiple atheroprotective effects in a murine FH model[2].

Molecular Weight	123.15
Formula	C7H9NO
CAS No.	932-30-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (365.39 mM)

References and Literature

1. O'Neill MJ, et al. 2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device. Trials. 2021 Aug 28;22(1):576. 2. Tao H, et al. Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice. Nat Commun. 2020 Aug 14;11(1):4084.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Traditional Chinese Medicine Monomer Library Clinical Compound Library Antioxidant Compound Library Bioactive Compounds Library Max Natural Product Library Bioactive Compound Library Alkaloid Natural Product Library Selected Plant-Sourced Compound Library RO5 Drug-like Natural Product Library

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Keywords

2-Hydroxybenzylamine 932-30-9 Others antioxidant IsoLGs inhibit Inhibitor atherosclerosis scavenger oxidative stress atrial fibrillation arrhythmias o-Hydroxybenzylamine FH model inflammation radical Reactive Oxygen Species 2-HOBA 2 Hydroxybenzylamine 2Hydroxybenzylamine inhibitor

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