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6-Hydroxykaempferol
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Catalog No. TN1314Cas No. 4324-55-4
6-Hydroxykaempferol, a competitive tyrosinase inhibitor (IC50=124 nM), belongs to the flavonoids class and is a natural product derived from Carthamus tinctorius. Compared with L-DOPA, 6-Hydroxykaempferol can bind to the active site of tyrosinase with higher activity and also has high antioxidant activity.
6-Hydroxykaempferol
😃Good
Catalog No. TN1314Cas No. 4324-55-4
6-Hydroxykaempferol, a competitive tyrosinase inhibitor (IC50=124 nM), belongs to the flavonoids class and is a natural product derived from Carthamus tinctorius. Compared with L-DOPA, 6-Hydroxykaempferol can bind to the active site of tyrosinase with higher activity and also has high antioxidant activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 1 mL x 10 mM (in DMSO) | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 6-Hydroxykaempferol, a competitive tyrosinase inhibitor (IC50=124 nM), belongs to the flavonoids class and is a natural product derived from Carthamus tinctorius. Compared with L-DOPA, 6-Hydroxykaempferol can bind to the active site of tyrosinase with higher activity and also has high antioxidant activity. |
| In vitro | Baicalein (1), 6-Hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-Hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. |
| Molecular Weight | 302.24 |
| Formula | C15H10O7 |
| Cas No. | 4324-55-4 |
| Smiles | O=C1C(O)=C(OC2=CC(O)=C(O)C(O)=C12)C=3C=CC(O)=CC3 |
| Relative Density. | 1.799 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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