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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $95 | In Stock | |
5 mg | $283 | In Stock | |
10 mg | $437 | In Stock | |
25 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | 740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone. |
Targets&IC50 | PI3K:20 μM |
In vitro | 740 Y-P TFA (1 μg/mL) stimulates Mitosis at the lowest concentration tested. The peptide stimulates Mitosis in the presence and absence of serum (0.5%). In the former instance, The maximum reaction was observed at 50 μg/mL. 740Y-P stimulation of Mitosis is highly specific, rather than the general characteristics of cell-permeable SH2 domain binding peptides. [1] 740 Y-P TFA (50 μg/ml; 48 h) in the culture medium, the specific stimulation of Mitosis was superior to EGF or FGF in stimulating the entry of S phase, which showed that the percentage of S phase cells in C2 cells was 48.3%. In addition, LY294002 or wortmannin effectively inhibited the Mitosis response stimulated by the 740Y-P TFA peptide. [1] 740 Y-P TFA (30 μM; 24 h) significantly inhibited the levels of LC3-II/LC3-I in GO induced PC12 cells. [2] |
Alias | PDGFR 740Y-P Acetate, 740YPDGFR acetate, 740 Y-P acetate(1236188-16-1 Free base) |
Molecular Weight | 3330.79 |
Formula | C143H226N43O41PS3 |
Cas No. |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | H2O: 83.3 mg/mL (25 mM) ![]() DMSO: 83.3 mg/mL (25 mM) ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O/DMSO
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