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740 Y-P acetate

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740 Y-P acetate

Catalog No. TQ0003L1

740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.

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Pack Size	Price	Availability
1 mg	$95	In Stock
5 mg	$283	In Stock
10 mg	$437	In Stock
25 mg	Inquiry	Backorder
50 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.
Targets&IC50	PI3K:20 μM
In vitro	740 Y-P TFA (1 μg/mL) stimulates Mitosis at the lowest concentration tested. The peptide stimulates Mitosis in the presence and absence of serum (0.5%). In the former instance, The maximum reaction was observed at 50 μg/mL. 740Y-P stimulation of Mitosis is highly specific, rather than the general characteristics of cell-permeable SH2 domain binding peptides. [1] 740 Y-P TFA (50 μg/ml; 48 h) in the culture medium, the specific stimulation of Mitosis was superior to EGF or FGF in stimulating the entry of S phase, which showed that the percentage of S phase cells in C2 cells was 48.3%. In addition, LY294002 or wortmannin effectively inhibited the Mitosis response stimulated by the 740Y-P TFA peptide. [1] 740 Y-P TFA (30 μM; 24 h) significantly inhibited the levels of LC3-II/LC3-I in GO induced PC12 cells. [2]
Alias	PDGFR 740Y-P Acetate, 740YPDGFR acetate, 740 Y-P acetate(1236188-16-1 Free base)

Chemical Properties

Molecular Weight	3330.79
Formula	C143H226N43O41PS3
Cas No.

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 83.3 mg/mL (25 mM)

DMSO: 83.3 mg/mL (25 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.3002 mL	1.5011 mL	3.0023 mL	15.0115 mL
5 mM	0.0600 mL	0.3002 mL	0.6005 mL	3.0023 mL
10 mM	0.0300 mL	0.1501 mL	0.3002 mL	1.5011 mL
20 mM	0.0150 mL	0.0751 mL	0.1501 mL	0.7506 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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