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8-Prenylkaempferol

8-Prenylkaempferol
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and IRF-3 and in part by interfering with IκB degradation which subsequently decreases NF-κB translocation.
Catalog No. TN1347Cas No. 28610-31-3
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8-Prenylkaempferol

Catalog No. TN1347Cas No. 28610-31-3
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and IRF-3 and in part by interfering with IκB degradation which subsequently decreases NF-κB translocation.
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Product Introduction

Bioactivity
Description
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and
In vitro
MC3T3-E1 cells were exposed to 8-Prenylkaempferol and the cytotoxicity was assayed. Osteoblast differentiation and maturation were evaluated by analyzing alkaline phosphatase (ALP) activity and cell mineralization, respectively. RT-PCR and Western blot were executed to determine the effects of 8-Prenylkaempferol on osteoblast differentiation-related gene expression and signaling pathway. 8-Prenylkaempferol significantly promoted ALP activity, up-regulated mRNA expressions of osteocalcin, osteopontin, and type I collagen, and induced bone nodules formation. Induction of differentiation by 8-Prenylkaempferol was associated with increased bone morphogenetic protein (BMP)-2 expression, and sequentially up-regulated the phosphorylations of Smad1/5/8 and p38, and increased the nuclear translocation of runt-related transcription factor 2 (Runx2). Addition of BMP-2 antagonist noggin blocked 8-Prenylkaempferol and recombinant mouse BMP-2-induced ALP activity, reconfirming that BMP-2 production is required in 8-Prenylkaempferol-mediated osteoblast differentiation. Noggin also abrogated 8-Prenylkaempferol evoked phosphorylations of Smad1/5/8 and p38, suggesting that BMP-2 signaling is required for p38 activation in 8-Prenylkaempferol-treated cells. Application of p38 inhibitor SB203580 repressed not only 8-Prenylkaempferol-mediated activation of ALP, but also the nuclear translocation of Runx2 and bone nodules formation[1]
Chemical Properties
Molecular Weight354.35
FormulaC20H18O6
Cas No.28610-31-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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