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AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study of Parkinson's disease.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | In Stock | |
5 mg | $106 | In Stock | |
10 mg | $159 | In Stock | |
25 mg | $289 | In Stock | |
50 mg | $438 | In Stock | |
100 mg | $658 | In Stock | |
200 mg | $919 | In Stock | |
1 mL x 10 mM (in DMSO) | $123 | In Stock |
Description | AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study of Parkinson's disease. |
Targets&IC50 | ERβ:6 nM (EC50), ERα:5000 nM (EC50) |
In vitro | In LNCaP cells, AC-186 (10 μM; 72 hours) inhibits the growth of LNCaP cells[1]. |
In vivo | In male Sprague-Dawley rats weighing 225-250 g, AC-186 (10 mg/kg; s.c.; once) prevented motor, cognitive, and sensorimotor gating deficits and mitigated the loss of dopamine neurons in the substantia nigra, but had no effect in females[1]. |
Alias | AC186, AC 186 |
Molecular Weight | 306.32 |
Formula | C18H17F3O |
Cas No. | 1421854-16-1 |
Smiles | FC=1C=CC=CC1C2(C3=CC=C(O)C=C3)CCC(F)(F)CC2 |
Relative Density. | no data available |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (261.16 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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