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ACH-806

Catalog No. T14095 CAS 870142-71-5

Synonyms: GS9132

ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ACH-806, CAS 870142-71-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.
Targets&IC50	HCV:（EC50）14 nM
In vitro	ACH-806, an NS4A antagonist, effectively hinders the replication of the Hepatitis C Virus (HCV) with an EC50 value of 14 nM. Treatment with ACH-806 notably decreases the immunoprecipitation levels of labeled NS3 and NS4A by anti-NS3 antibody. It significantly reduces NS3 and NS4A levels and facilitates p14 formation in original replicon cells, albeit not affecting ACH-806-resistant cells[1]. Moreover, ACH-806 administration leads to notable reductions in NS3 and NS4A within transfected cells, mirroring effects observed in replicon cells treated with the compound, where both NS3 and NS4A levels decrease significantly. Following ACH-806 treatment, NS3 amounts are diminished approximately 6-fold (100/16), and NS4A-bound NS3 is reduced roughly 29-fold (261/9).

Synonyms	GS9132
Molecular Weight	411.44
Formula	C19H20F3N3O2S
CAS No.	870142-71-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yang W, et al. ACH-806, an NS4A antagonist, inhibits hepatitis C virus replication by altering the composition of viral replication complexes. Antimicrob Agents Chemother. 2013 Jul;57(7):3168-77.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ACH-806 870142-71-5 Microbiology/Virology Proteases/Proteasome HCV Protease GS9132 GS 9132 ACH806 GS-9132 ACH 806 inhibitor inhibit

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