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AM-8735
Catalog No. T14203Cas No. 1429386-01-5
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
AM-8735
Catalog No. T14203Cas No. 1429386-01-5
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM). |
| Targets&IC50 | MDM2:25 nM |
| In vitro | AM-8735 exhibits a dose-dependent increase of p21 mRNA, a direct transcriptional readout of p53 activity, in HCT116 p53wt cells (IC50=160 nM)[1]. AM-8735 displays substantial growth inhibition of wild-type p53 cells (IC50=63 nM) and no growth inhibition of p53-deficient cells (IC50>25 μM). |
| In vivo | AM-8735 exhibits potent antitumor properties in the SJSA-1 osteosarcoma xenograft model, achieving an effective dose (ED50) of 41 mg/kg[1]. Additionally, AM-8735 significantly induces p21 mRNA expression in a time- and concentration-dependent manner within SJSA-1 osteosarcoma tumors, as demonstrated through in vivo pharmacodynamic assays. |
| Molecular Weight | 568.51 |
| Formula | C27H31Cl2NO6S |
| Cas No. | 1429386-01-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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