Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

APX-115

APX-115
APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
Catalog No. T10354Cas No. 1395946-75-4
Select Batch
Purity:99.68%
Contact us for more batch information
Resource Download

APX-115

Catalog No. T10354Cas No. 1395946-75-4
APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$73In Stock
10 mg$118In Stock
25 mg$247In Stock
50 mg$370In Stock
100 mg$527In Stock
500 mg$1,070In Stock
1 mL x 10 mM (in DMSO)$98In Stock
Bulk & Custom
Add to Cart

Related Compound Libraries of "APX-115"

Product Introduction

Bioactivity
Description
APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
Targets&IC50
NOX2:0.57 μM (ki), Nox4:0.63 μM (ki), NOX1:ki:1.08 μM
In vitro
In the mouse podocyte cell line, APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes [2].
In vivo
APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice[1].
AliasEwha-18278
Chemical Properties
Molecular Weight315.8
FormulaC17H18ClN3O
Cas No.1395946-75-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (285 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1666 mL15.8328 mL31.6656 mL158.3281 mL
5 mM0.6333 mL3.1666 mL6.3331 mL31.6656 mL
10 mM0.3167 mL1.5833 mL3.1666 mL15.8328 mL
20 mM0.1583 mL0.7916 mL1.5833 mL7.9164 mL
50 mM0.0633 mL0.3167 mL0.6333 mL3.1666 mL
100 mM0.0317 mL0.1583 mL0.3167 mL1.5833 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy APX-115 | purchase APX-115 | APX-115 cost | order APX-115 | APX-115 chemical structure | APX-115 in vivo | APX-115 in vitro | APX-115 formula | APX-115 molecular weight