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AS8351

Catalog No. T4100 CAS 796-42-9

Synonyms: NSC51355, AS-8351, AS 8351

AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AS8351, CAS 796-42-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 118.00
50 mg	In stock	$ 198.00
100 mg	In stock	$ 369.00
200 mg	In stock	$ 479.00
500 mg	In stock	$ 785.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 99.80%

Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	NSC51355, AS-8351, AS 8351
Molecular Weight	291.3
Formula	C17H13N3O2
CAS No.	796-42-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 29.1 mg/mL(100 mM)

References and Literature

1. Cao, N.,Huang, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352(6290), 1216-1220 (2016).

Citations

1. Chen B, Chen H, Lu S, et al. KDM5B promotes tumorigenesis of Ewing sarcoma via FBXW7/CCNE1 axis. Cell Death & Disease. 2022, 13(4): 1-13

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Methylation Compound Library Anti-Aging Compound Library Histone Modification Compound Library Chromatin Modification Compound Library Epigenetics Compound Library Bioactive Compound Library Bioactive Compounds Library Max Stem Cell Differentiation Compound Library

Related Products

Related compounds with same targets

TAK-418 KDM4C-IN-1 KF 13218 LSD1-IN-6 KF21213 LSD1-IN-27 KDM5-C70 PBIT

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AS8351 796-42-9 Chromatin/Epigenetic Histone Demethylase NSC51355 AS-8351 AS 8351 inhibit Inhibitor NSC-51355 NSC 51355 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.