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BMS-303141

Catalog No. T2337 CAS 943962-47-8

Synonyms: BMS 303141

BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BMS-303141, CAS 943962-47-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 61.00
10 mg	In stock	$ 79.00
25 mg	In stock	$ 143.00
50 mg	In stock	$ 282.00
100 mg	In stock	$ 443.00
500 mg	In stock	$ 992.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 99.47%

Purity: 99.21%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
Targets&IC50	ACL:0.13 μM
In vitro	BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM in HepG2 cells. BMS-303141 shows no cytotoxicity up to 50 lM under a cell-based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity[1].
In vivo	Chronic oral administration of BMS-303141 to mice on a high-fat diet reduces plasma cholesterol and triglycerides by approximately 20-30% and fasting plasma glucose by 30-50%. Continued treatment with BMS-303141 gradually inhibits weight gain and decreases adiposity without affecting food consumption. BMS-303141 displays an oral bioavailability of 55% and a relatively brief half-life of 2.1 hours[1].

Synonyms	BMS 303141
Molecular Weight	424.3
Formula	C19H15Cl2NO4S
CAS No.	943962-47-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (129.63 mM)

References and Literature

1. Li JJ, et al. 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11.

Citations

1. Tang C, Wang H, Guo L, et al.CpG-Conjugated Silver Nanoparticles as a Multifunctional Nanomedicine to Promote Macrophage Efferocytosis and Repolarization for Atherosclerosis Therapy.ACS Applied Materials & Interfaces.2023

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Lipid Metabolism Compound Library Bioactive Compounds Library Max Metabolism Compound Library Bioactive Compound Library Anti-Metabolism Disease Compound Library Target-Focused Phenotypic Screening Library

Related Products

Related compounds with same targets

Forrestiacids K Forrestiacids J MEDICA16 (-)-Hydroxycitric acid lactone Hydroxycitric acid tripotassium hydrate 2-Furoic acid (-)-Hydroxycitric acid NDI-091143

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-303141 943962-47-8 Metabolism ATP Citrate Lyase inhibit BMS303141 BMS 303141 Inhibitor ACLY inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.