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SB 204990
SB 204990 is a lactone prodrug of SB-201076, a potent and specific ATP citrate lyase inhibitor.
Catalog No. T16861Cas No. 154566-12-8
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Purity:99.6%
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SB 204990
Catalog No. T16861Cas No. 154566-12-8
SB 204990 is a lactone prodrug of SB-201076, a potent and specific ATP citrate lyase inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $93 | In Stock | |
| 10 mg | $163 | In Stock | |
| 25 mg | $323 | In Stock | |
| 50 mg | $593 | In Stock | |
| 100 mg | $848 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB 204990 is a lactone prodrug of SB-201076, a potent and specific ATP citrate lyase inhibitor. |
| In vitro | METHODS: Primary hepatocytes were treated with SB-204990 (10 μM, 16 hours) under different experimental conditions to determine the effects occurring early after exposure to the Acly inhibitor SB-204990. RESULTS Phosphorylation of pThr 172 Ampk and pSer 79 Acc was reduced in primary hepatocytes treated with SB-204990 for 16 hours, while markers of Sirt1 or mTOR activity were absent. [1] |
| In vivo | METHODS: Mice were treated with SB-204990 (30 mg/kg body weight; oral gavage; treatment for 3 hours) to determine whether SB-204990 could induce effects in mitochondria in vivo. RESULTS Freshly isolated liver mitochondria from mice showed blocking and limiting effects on ADP-induced and FCCP-induced increases in OCR, respectively. [1] |
| Molecular Weight | 389.27 |
| Formula | C18H22Cl2O5 |
| Cas No. | 154566-12-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (256.89 mM) H2O: 10 mg/mL (25.69 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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