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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
5 mg | $93 | In Stock | |
10 mg | $163 | In Stock | |
25 mg | $323 | In Stock | |
50 mg | $593 | In Stock | |
100 mg | $848 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor. |
In vitro | SB204990 treatment leads to a reduction in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels [1]. |
In vivo | When administered orally to rats, SB 204990 achieves systemic circulation and induces a dose-related reduction in plasma cholesterol (up to 46%) and triglyceride levels (up to 80%) upon inclusion in their diet at 0.05-0.25% (w/w) for one week. Similarly, a daily dose of 25 mg/kg of SB 204990 in dogs decreases plasma cholesterol (up to 23%) and triglyceride levels (up to 38%), with a preferential reduction in low-density lipoprotein compared to high-density lipoprotein cholesterol levels [2]. |
Molecular Weight | 389.27 |
Formula | C18H22Cl2O5 |
Cas No. | 154566-12-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (256.89 mM) H2O: 10 mg/mL (25.69 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
DMSO
|
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