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BMS-303141
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
Catalog No. T2337Cas No. 943962-47-8
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Purity:99.47%
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BMS-303141
Catalog No. T2337Alias BMS 303141Cas No. 943962-47-8
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $39 | In Stock | |
| 5 mg | $61 | In Stock | |
| 10 mg | $79 | In Stock | |
| 25 mg | $143 | In Stock | |
| 50 mg | $282 | In Stock | |
| 100 mg | $443 | In Stock | |
| 500 mg | $992 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $63 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL). |
| Targets&IC50 | ACL:0.13 μM |
| In vitro | BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM in HepG2 cells. BMS-303141 shows no cytotoxicity up to 50 lM under a cell-based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity[1]. |
| In vivo | Chronic oral administration of BMS-303141 to mice on a high-fat diet reduces plasma cholesterol and triglycerides by approximately 20-30% and fasting plasma glucose by 30-50%. Continued treatment with BMS-303141 gradually inhibits weight gain and decreases adiposity without affecting food consumption. BMS-303141 displays an oral bioavailability of 55% and a relatively brief half-life of 2.1 hours[1]. |
| Alias | BMS 303141 |
| Molecular Weight | 424.3 |
| Formula | C19H15Cl2NO4S |
| Cas No. | 943962-47-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (129.63 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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