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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
2 mg | $63 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $168 | In Stock | |
25 mg | $283 | In Stock | |
50 mg | $422 | In Stock | |
100 mg | $613 | In Stock | |
1 mL x 10 mM (in DMSO) | $185 | In Stock |
Description | Bradykinin (2-9) (Des-Arg1-bradykinin) is an amino-truncated peptide compound that is a metabolite of Bradykinin. It is formed by the cleavage action of Aminopeptidase P. |
In vitro | The Bradykinin peptide system, crucial for cardiovascular and renal functions, is examined using a highly sensitive amino terminal-directed radioimmunoassay combined with high-performance liquid chromatography. This method allows for the precise measurement of various Bradykinin peptides, including Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9). An additional carboxy terminal-directed radioimmunoassay facilitates the characterization of these peptides in rat kidney and blood. The primary findings indicate that Bradykinin-(1-9) and Bradykinin-(1-7) are the most abundant in the kidney, with significantly lower concentrations of Bradykinin-(1-8) and Bradykinin-(4-9), while Bradykinin-(2-9) and Bradykinin-(3-9) are undetectable. Blood analysis shows very low levels of Bradykinin-(1-9), with other peptides falling below detection thresholds. Administration of the ACE inhibitor Perindopril significantly increases renal levels of Bradykinin-(1-8) and Bradykinin-(1-9), altering the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. This radioimmunoassay approach is also effectively applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain tissues, identifying similar abundance levels of Bradykinin-(1-7) and Bradykinin-(1-9), with Bradykinin-(1-8) present in lower amounts. |
Alias | Des-Arg1-bradykinin |
Molecular Weight | 904.02 |
Formula | C44H61N11O10 |
Cas No. | 16875-11-9 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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