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MK-0686

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Catalog No. T33421Cas No. 578727-68-1
Alias MK0686

MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.

MK-0686

MK-0686

🥰Excellent
Purity: 99.56%
Catalog No. T33421Alias MK0686Cas No. 578727-68-1
MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.
Pack SizePriceAvailabilityQuantity
1 mg$191In Stock
5 mg$470In Stock
10 mg$689In Stock
25 mg$1,080In Stock
50 mg$1,460In Stock
100 mg$1,960In Stock
500 mg$3,930In Stock
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Purity:99.56%
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Product Introduction

Bioactivity
Description
MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.
AliasMK0686
Chemical Properties
Molecular Weight486.84
FormulaC22H19ClF4N2O4
Cas No.578727-68-1
SmilesC(N[C@H](C)C1=C(F)C=C(C=C1)C2=C(C(OC)=O)C(Cl)=CC=C2)(=O)C3(NC(C(F)(F)F)=O)CC3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (102.7 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0541 mL10.2703 mL20.5406 mL102.7031 mL
5 mM0.4108 mL2.0541 mL4.1081 mL20.5406 mL
10 mM0.2054 mL1.0270 mL2.0541 mL10.2703 mL
20 mM0.1027 mL0.5135 mL1.0270 mL5.1352 mL
50 mM0.0411 mL0.2054 mL0.4108 mL2.0541 mL
100 mM0.0205 mL0.1027 mL0.2054 mL1.0270 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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