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Safotibant
Catalog No. T34485Cas No. 633698-99-4
Alias LF22-0542, LF-22-0542, LF-220542, LF220542, LF 22-0542, LF 220542
Safotibant (LF-22-0542) is a bradykinin B1 receptor antagonist with anti-inflammatory and analgesic activity for the topical treatment of diabetic macular edema.
Safotibant
Catalog No. T34485Alias LF22-0542, LF-22-0542, LF-220542, LF220542, LF 22-0542, LF 220542Cas No. 633698-99-4
Safotibant (LF-22-0542) is a bradykinin B1 receptor antagonist with anti-inflammatory and analgesic activity for the topical treatment of diabetic macular edema.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $146 | In Stock | |
| 5 mg | $350 | In Stock | |
| 10 mg | $530 | In Stock | |
| 25 mg | $859 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,590 | In Stock | |
| 500 mg | $3,190 | In Stock |
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Purity:99.53%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Safotibant (LF-22-0542) is a bradykinin B1 receptor antagonist with anti-inflammatory and analgesic activity for the topical treatment of diabetic macular edema. |
| In vivo | LF22-0542 (1% in saline; eye drop; twice a day for 7 days; diabetic rats) significantly reduced Retinal plasma extravasation, leukostasis, and mRNA levels of B(1)R, iNOS, COX-2, VEGF receptor type 2, IL-1β and HIF-1α to the control value level.[1] |
| Alias | LF22-0542, LF-22-0542, LF-220542, LF220542, LF 22-0542, LF 220542 |
| Molecular Weight | 502.63 |
| Formula | C25H34N4O5S |
| Cas No. | 633698-99-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (99.48 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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