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Buflomedil hydrochloride

Catalog No. T0317 CAS 35543-24-9

Synonyms: Buflomedil HCl, Fonzylane, Loftyl

Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.

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Buflomedil hydrochloride Chemical Structure

Buflomedil hydrochloride, CAS 35543-24-9

Pack Size	Availability	Price/USD
100 mg	In stock	$ 58.00
500 mg	In stock	$ 90.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.7%

Purity: 99.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.

In vitro

Buflomedil enhances intracellular cAMP levels in human keratinocytes, either secondary to adenyl-cyclase stimulation (BC) or phosphodiesterase inhibition (PTX). Buflomedil diminishes release of TPA-induced TNF-alpha and IL-8 in keratinocytes; in the case of IL-8, this inhibition may occur to transcriptional level. At the micromolar level, Buflomedil notably inhibits epinephrine-induced aggregation. Buflomedil leads to a weak inhibition of collagen- and ADP-induced aggregation. Buflomedil inhibits grainy secretion and the interaction of fibrinogen with its receptor on platelet. the capillary perfusion is improved by Buflomedil hypochloride in such related situations, evoking a possible effect upon neutrophils. Buflomedil Completely inhibits adhesion of histamine related neutrophil (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil lowers the hypoxia-induced neutrophil adhesion and expression of P-selectin at the surface of endothelial cells.

Synonyms	Buflomedil HCl, Fonzylane, Loftyl
Molecular Weight	343.85
Formula	C17H26ClNO4
CAS No.	35543-24-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 7 mg/mL (20.35 mM)

H2O: 63 mg/mL (183.2 mM)

DMSO: 29 mg/mL (84.3 mM)

References and Literature

1. Ishitsuka Y, et al. J Pharmacol Sci,2009, 111(2), 211-215. 2. Imamura T, et al. Arzneimittelforschung,2003, 53(10), 688-694. 3. Ichikawa K, et al. Pharmacology,1999, 59(5), 257-265. 4. Ishitsuka Y, et al. J Pharm Pharmacol,2004, 56(4), 513-520.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Anti-Hypertension Compound Library Endocrinology-Hormone Compound Library

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Keywords

Buflomedil hydrochloride 35543-24-9 GPCR/G Protein Neuroscience Adrenergic Receptor Buflomedil inhibit Buflomedil HCl Fonzylane Inhibitor Loftyl Buflomedil Hydrochloride inhibitor

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