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CAL-101

Catalog No. T8651   CAS 1146702-54-6
Synonyms: (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, GS-1101, Idelalisib

CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.

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CAL-101 Chemical Structure
CAL-101, CAS 1146702-54-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 30.00
10 mg In stock $ 43.00
25 mg In stock $ 70.00
50 mg In stock $ 89.00
100 mg In stock $ 128.00
200 mg In stock $ 193.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.39%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
Targets&IC50 p110γ(Cell-free assay):89 nM, p110δ(Cell-free assay):2.5 nM
In vitro CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and caspase cleavage and an induction of apoptosis[1].
Synonyms (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, GS-1101, Idelalisib
Molecular Weight 401.4
Formula C21H16FN7O
CAS No. 1146702-54-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (60.18 mM)

TargetMolReferences and Literature

1. Brian J Lannutti, Sarah A Meadows, Sarah E M Herman,et al.CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.Blood. 2011 Jan 13;117(2):591-4. 2. Sarah E M Herman , Amber L Gordon, Amy J Wagner,et al.Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals.Blood. 2010 Sep 23;116(12):2078-88.

TargetMolCitations

1. Zhang X, Dai Q, Shan J, et al.Inhibition of phosphoinositide‑3 kinases γ/δ ameliorates pulmonary granuloma by rescuing Treg function in a sarcoidosis model.Experimental and Therapeutic Medicine.2023, 25(5): 1-11.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library FDA-Approved & Pharmacopeia Drug Library Drug-induced Liver Injury (DILI) Compound Library Anti-Lung Cancer Compound Library Reprogramming Compound Library Bioactive Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Metabolism Compound Library

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mTOR inhibitor 13 LY-294002 hydrochloride Sapanisertib mTOR inhibitor 9f PI3K-IN-38 Rigosertib sodium IPI-3063 Isoangustone A

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CAL-101 1146702-54-6 PI3K/Akt/mTOR signaling PI3K CAL101 (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one CAL 101 GS-1101 GS1101 GS 1101 Idelalisib inhibitor inhibit

 

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