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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $83 | In Stock | |
5 mg | $167 | In Stock | |
10 mg | $253 | In Stock | |
25 mg | $425 | In Stock | |
50 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $196 | In Stock |
Description | CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM. |
Targets&IC50 | RARβ:306 nM(ki), RARγ:(ki)110 nM |
In vitro | In 3T3 cells, CD2665 (100 nM) abrogates the antiproliferative effects of ATRA, CD271 (adapalene, a RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level[1]. |
In vivo | In mice submitted to 10 months of ethanol consumption, CD2665 (0.6 mg/kg; s.c.) decreases brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels[2]. |
Molecular Weight | 486.6 |
Formula | C31H34O5 |
Cas No. | 170355-78-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (46.2 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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