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CD2665
CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
Catalog No. T14911Cas No. 170355-78-9
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Purity:99.67%
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CD2665
Catalog No. T14911Cas No. 170355-78-9
CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $83 | In Stock | |
| 5 mg | $167 | In Stock | |
| 10 mg | $253 | In Stock | |
| 25 mg | $425 | In Stock | |
| 50 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $196 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM. |
| Targets&IC50 | RARβ:306 nM(ki), RARγ:（ki）110 nM |
| In vitro | In 3T3 cells, CD2665 (100 nM) abrogates the antiproliferative effects of ATRA, CD271 (adapalene, a RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level[1]. |
| In vivo | In mice submitted to 10 months of ethanol consumption, CD2665 (0.6 mg/kg; s.c.) decreases brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels[2]. |
| Molecular Weight | 486.6 |
| Formula | C31H34O5 |
| Cas No. | 170355-78-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (46.2 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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