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CGK733
🥰Excellent
Catalog No. T1821Cas No. 905973-89-9
Alias CGK 733
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
CGK733
🥰Excellent
Purity: 99.7%
Catalog No. T1821Alias CGK 733Cas No. 905973-89-9
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $30 | In Stock | |
| 10 mg | $51 | In Stock | |
| 25 mg | $97 | In Stock | |
| 50 mg | $179 | In Stock | |
| 100 mg | $355 | In Stock | |
| 500 mg | $842 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99.7%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR. |
| In vivo | In senescent cells with halted proliferation, treatment with CGK733 leads to the disappearance of senescence-associated beta-galactosidase (SA-β-gal) activity, enabling the cells to proliferate. In aged MCF-7 cells, 24-hour treatment with CGK733 (30 μM) can induce cell death. Furthermore, in various cancer cells, such as MCF-7 and T47D estrogen receptor (ER) positive breast cancer cells, MDA-MB436 ER-negative breast cancer cells, LnCap precursor cancer cells, and HCT116 colon cancer cells, CGK733 (0.6-40 μM) has the capability to inhibit proliferation. |
| Alias | CGK 733 |
| Molecular Weight | 555.84 |
| Formula | C23H18Cl3FN4O3S |
| Cas No. | 905973-89-9 |
| Smiles | [O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c2ccccc2)C(Cl)(Cl)Cl)ccc1F |
| Relative Density. | 1.502 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (179.9 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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