Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 30.00 | |
10 mg | In stock | $ 51.00 | |
25 mg | In stock | $ 97.00 | |
50 mg | In stock | $ 179.00 | |
100 mg | In stock | $ 355.00 | |
500 mg | In stock | $ 842.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR. |
In vivo | In senescent cells with halted proliferation, treatment with CGK733 leads to the disappearance of senescence-associated beta-galactosidase (SA-β-gal) activity, enabling the cells to proliferate. In aged MCF-7 cells, 24-hour treatment with CGK733 (30 μM) can induce cell death. Furthermore, in various cancer cells, such as MCF-7 and T47D estrogen receptor (ER) positive breast cancer cells, MDA-MB436 ER-negative breast cancer cells, LnCap precursor cancer cells, and HCT116 colon cancer cells, CGK733 (0.6-40 μM) has the capability to inhibit proliferation. |
Synonyms | CGK 733 |
Molecular Weight | 555.84 |
Formula | C23H18Cl3FN4O3S |
CAS No. | 905973-89-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (179.9 mM)
You can also refer to dose conversion for different animals. More
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CGK733 905973-89-9 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR Inhibitor inhibit CGK 733 ATM and RAD3 related Ataxia telangiectasia mutated CGK-733 inhibitor