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CMS-121

Catalog No. T14991 CAS 1353224-53-9

Synonyms: CMS121

CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.

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CMS-121, CAS 1353224-53-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 37.00
5 mg	In stock	$ 61.00
10 mg	In stock	$ 95.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 266.00
100 mg	In stock	$ 397.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

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Purity: 99.48%

Biological Description

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Storage & Solubility Information

Description	CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.
In vitro	CMS-121 can increase acetyl-CoA in cells. CMS-121 (1 μM; 4 hours; HT22 cells) treatment also increases the phosphorylation of ACC1 at serine 79.[1].
In vivo	CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS-121 (~20 mg/kg; p.o; daily; for 4 months; female SAMP8 mice) treatment decreases cognitive decline and metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. [1].

Synonyms	CMS121
Molecular Weight	321.37
Formula	C20H19NO3
CAS No.	1353224-53-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (155.58 mM), Sonication is recommended.

References and Literature

1. Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866. 2. Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89. 3. Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Antioxidant Compound Library Bioactive Compounds Library Max Anti-Hypertension Compound Library Orally Active Compound Library Lipid Metabolism Compound Library Oxidation-Reduction Compound Library Bioactive Compound Library Metabolism Compound Library Immunology/Inflammation Compound Library

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Keywords

CMS-121 1353224-53-9 Metabolism Acetyl-CoA Carboxylase ACC, Acetyl Coenzyme A Carboxylase CMS 121 disease neuroprotective inhibit anti-inflammatory mitochondrial Alzheimer's antioxidative acetylation Inhibitor H3K9 CMS121 dementia ACC1 inhibitor

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