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Cefodizime

Catalog No. T14922 CAS 69739-16-8

Cefodizime is a third-generation cephalosporin Antibiotic with a broad spectrum of Antibacterial activity. Cefodizime has no renal toxic effect, good tolerance, and immune regulation activity.

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Cefodizime, CAS 69739-16-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cefodizime is a third-generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime has no renal toxic effect, good tolerance, and immune regulation activity.
In vitro	Cefodizime is a bactericidal antibiotic having a high affinity for penicillin-binding proteins lA/B, 2, and 3 of E. coli. Cefodizime inhibits other Gram-negative bacteria including Haemophilus irifluenzae, Neisseria gonorrhoeae, Moraxella catarrhalis, and Neisseria meningitidis. Cefodizime has marginal but variable inhibitory activity against Citrobacter species including Serratia marcescens and Citrobacter freundii. The in vitro concentrations of Cefodizime resulting in bactericidal activity against susceptible strains of Gram-positive and Gram-negative bacteria are generally similar to the minimum inhibitory concentrations [1].
In vivo	Cefodizime has activity comparable to Cefotaxime and Ceftazidime, and greater than that of Cefoperazone, Latamoxef, Cefuroxime, or cefazolin for 8 hours after a single subcutaneous dose of 50 mg/kg, in experimentally-induced K. pneumoniae respiratory tract infections in mice. However, unlike these cephalosporins, Cefodizime continues to demonstrate pronounced bactericidal activity for at least 48 hours after a single injection. Complete bacterial clearance from the lung is achieved within 48 hours in 50% of the mice although Cefodizime is no longer detectable in the serum [1].

Molecular Weight	584.67
Formula	C20H20N6O7S4
CAS No.	69739-16-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 20.83 mg/mL (35.63 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Barradell LB, et al. Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1992 Nov;44(5):800-34. 2. Hu T, et al. Probing the interaction of cefodizime with human serum albumin using multi-spectroscopic and molecular docking techniques. J Pharm Biomed Anal. 2015 Mar 25;107:325-32.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cefodizime 69739-16-8 Microbiology/Virology Antibacterial Inhibitor inhibitor inhibit

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