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Chicanine

Catalog No. TN1485 CAS 78919-28-5

Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.

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Chicanine, CAS 78919-28-5

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10 mg	Inquiry	$ 550.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 390.00

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Description	Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
In vitro	In this study, Chicanine, one of the major lignan compounds of S. chinesis, was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (RAW 264.7 cells). Chicanine was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO) and Prostaglandin E (2) (PGE2) production and nuclear factor-κB (NF-κB) signaling in LPS-stimulated RAW 264.7 cells with no cytotoxic effects. Treatment of RAW 264.7 cells with Chicanine down-regulated LPS-induced expression of pro-inflammatory cytokines including TNFα±, IL-1β, MCP-1, G-CSF, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK 1/2), and also IκB-α± phosphorylation[1]
Source	Natural Products > Oleaceae > Osmanthus

Molecular Weight	342.39
Formula	C20H22O5
CAS No.	78919-28-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathwaysEur J Pharmacol. 2014 Feb 5;724:168-74.

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Keywords

Chicanine 78919-28-5 GPCR/G Protein Immunology/Inflammation NF-Κb Others Prostaglandin Receptor NF-κB inhibitor inhibit

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