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Chloramphenicol

Catalog No. T1205   CAS 56-75-7
Synonyms: Chlornitromycin, Levomycetin, Chloromycetin

Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.

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Chloramphenicol Chemical Structure
Chloramphenicol, CAS 56-75-7
Pack Size Availability Price/USD Quantity
500 mg In stock $ 41.00
1 g In stock $ 48.00
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Purity: 99.89%
Purity: 99.72%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
In vitro In animal studies, Chloramphenicol induces increased lipid peroxidation in the liver during the (gigantic mitochondria) formation stage, while concurrently inhibiting an increase in liver weight.
In vivo Chloramphenicol (>0.1 g/L) inhibits denitrification enzyme activity (DEA) in humic and sandy loam soils by blocking the activity of nitrate reductase. In cell lines derived from monkey kidneys and hematopoietic progenitor cells from human neonatal umbilical cord blood, chloramphenicol (2-5 mM) suppresses progenitor cell growth and induces apoptosis.
Synonyms Chlornitromycin, Levomycetin, Chloromycetin
Molecular Weight 323.13
Formula C11H12Cl2N2O5
CAS No. 56-75-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 60 mg/mL (185.7 mM)

DMSO: 60 mg/mL (185.7 mM)

TargetMolReferences and Literature

1. Jiang W, et al. J Bacteriol, 1993, 175(18), 5824-5828. 2. Li CH, et al. J Biol Chem, 2005, 280(28), 26193-26199. 3. Murray RE, et al. Appl Environ Microbiol, 1999, 65(8), 3487-3492. 4. Mandsager RE, et al. Am J Vet Res, 1995, 56(1), 95-99. 5. Stearns ME, et al. Invasion Metastasis, 1996, 16(3), 116-131. 6. Chen Y, Zhu Y, Shen M, et al. Rapid and automated detection of six contaminants in milk using a centrifugal microfluidic platform with two rotation axes[J]. Analytical Chemistry. 2019 May 24.

TargetMolCitations

1. Chen Y, Zhu Y, Shen M, et al. Rapid and automated detection of six contaminants in milk using a centrifugal microfluidic platform with two rotation axes. Analytical Chemistry. 2019 May 24

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Drug Repurposing Compound Library Natural Product Library NO PAINS Compound Library Natural Product Library for HTS RO5 Drug-like Natural Product Library Anti-Infection Compound Library Human Metabolite Library Anti-Bacterial Compound Library Drug-induced Liver Injury (DILI) Compound Library

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Keywords

Chloramphenicol 56-75-7 Chromatin/Epigenetic Metabolism Microbiology/Virology ribosome HIF/HIF Prolyl-Hydroxylase Antibacterial Antibiotic Vascular endothelial growth factor receptor inhibit Chlornitromycin Aplastic anaemia Levomycetin VEGFR Inhibitor Atg6 MMP Matrix metalloproteinases JNK Chloromycetin SENP-1 A549 Protein kinase B HIFs Akt PKB Beclin1 Bacterial anaerobic infections H1299 Apoptosis PI-3K HIF-PH mitochondria stress Hypoxia-inducible factors Autophagy inhibitor

 

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