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Citreorosein

Catalog No. TN1504 CAS 481-73-2

Synonyms: 羟基大黄素

Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.

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Citreorosein, CAS 481-73-2

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Purity: 98%

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Description

In vitro

Citreorosein suppresses both degranulation and the generation of LTC(4) in a dose-dependent manner in stem cell factor (SCF)-mediated mouse bone marrow-derived mast cells (BMMCs). With regard to its molecular mechanism of action, we investigated the effects of Citreorosein on intracellular signaling and mast cell activation employing BMMCs. Binding of SCF to c-Kit on mast cell membranes induced increases in intrinsic tyrosine kinase Syk activity and activation of multiple downstream events including phosphorylation of phospholipase Cγ (PLCγ), mobilization of intracellular Ca(2+), phosphatidylinositol 3-kinase (PI3K), Akt, MAP kinases (MAPKs), translocation of phospho-phospholipase A(2) (PLA(2)) and 5-LO.

Synonyms	羟基大黄素
Molecular Weight	286.239
Formula	C15H10O6
CAS No.	481-73-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Citreorosein inhibits degranulation and leukotriene C₄ generation through suppression of Syk pathway in mast cells.Mol Cell Biochem. 2012 Jun;365(1-2):333-41.

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Keywords

Citreorosein 481-73-2 G蛋白偶联受体 NF-Kb信号通路 PI3K/Akt/mTOR信号通路 cAMP NF-κB PI3K Inhibitor inhibitor inhibit

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