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DJ001
Catalog No. T11053Cas No. 2161305-12-8
DJ001 is a highly specific, selective, and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with an IC50 of 1.43 μM, and it promotes the regeneration of hematopoietic stem cells.
DJ001
Catalog No. T11053Cas No. 2161305-12-8
DJ001 is a highly specific, selective, and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with an IC50 of 1.43 μM, and it promotes the regeneration of hematopoietic stem cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 2 mg | $85 | In Stock | |
| 5 mg | $143 | In Stock | |
| 10 mg | $223 | In Stock | |
| 25 mg | $369 | In Stock | |
| 50 mg | $520 | In Stock | |
| 100 mg | $696 | In Stock | |
| 500 mg | $1,390 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $157 | In Stock |
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Purity:98.21%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DJ001 is a highly specific, selective, and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with an IC50 of 1.43 μM, and it promotes the regeneration of hematopoietic stem cells. |
| Targets&IC50 | PTPσ:1.43 μM |
| In vitro | Compared with control culture, DJ001 (5-1000 ng/mL; 3-7 days; BM KSL cells) treatment can increase the percentage and number of BM KSL cells in culture. DJ001 treatment also significantly increased the number of colony forming cells (CFC) in BM KSL cells cultured for 3 days. The BM KSL cells were irradiated with 300 cGy and placed in a medium containing 1 μg/mL DJ001 and without 1 μg/mL DJ001 (containing 20 μng/mL thrombopoietin, 100 μng/mL stem cell factor (SCF), 50 μng/mL Flt3 Body, TSF). 3 days. Compared with control culture, DJ001 treatment can improve the recovery rate of BM CFC and multipotent colony forming unit-granulocyte-like erythrocyte mononuclear megakaryocyte (CFU-GEMM) colonies[1]. |
| In vivo | DJ001 inhibits radiation-induced HSC apoptosis by activating RhoGTPase, RAC1 and inducing BCL-XL. DJ001 (5 μg/kg; subcutaneous injection; duration 24 hours; female C57BL/6 mice) significantly reduced the percentage of apoptotic BM KSL cells in C57BL/6 mice 24h after 500°cGy TBI[1]. |
| Molecular Weight | 268.27 |
| Formula | C15H12N2O3 |
| Cas No. | 2161305-12-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225 mg/mL (838.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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