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Dibenz[a,h]anthracene

Catalog No. T31425 CAS 53-70-3

Synonyms: DB(a,h)A, CCRIS 208

Dibenz[a,h]anthracene has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.

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Dibenz[a,h]anthracene, CAS 53-70-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Dibenz[a,h]anthracene has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.

Synonyms	DB(a,h)A, CCRIS 208
Molecular Weight	278.35
Formula	C22H14
CAS No.	53-70-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 3.6 mg/mL (12.93 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Padilla-Chavarría HI, Guizado TR, Pimentel AS. Molecular dynamics of dibenz[a,h]anthracene and its metabolite interacting with lung surfactant phospholipid bilayers. Phys Chem Chem Phys. 2015 Aug 28;17(32):20912-22. doi: 10.1039/c5cp01443c. Epub 2015 Jul 27. PubMed PMID: 26214736. 2. Chang RL, Wood AW, Huang MT, Xie JG, Cui XX, Reuhl KR, Boyd DR, Lin Y, Shih WJ, Balani SK, Yagi H, Jerina DM, Conney AH. Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene. Carcinogenesis. 2013 Sep;34(9):2184-91. doi: 10.1093/carcin/bgt164. Epub 2013 May 13. PubMed PMID: 23671133; PubMed Central PMCID: PMC3765047. 3. Malik AI, Rowan-Carroll A, Williams A, Lemieux CL, Long AS, Arlt VM, Phillips DH, White PA, Yauk CL. Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene. Mutagenesis. 2013 Sep;28(5):543-54. doi: 10.1093/mutage/get031. Epub 2013 Jun 21. PubMed PMID: 23793610. 4. Kim JH, Kim WK. Use of the Integrated Biomarker Response to Measure the Effect of Short-term Exposure to Dibenz[a,h]anthracene in Common carp (Cyprinus carpio). Bull Environ Contam Toxicol. 2016 Apr;96(4):496-501. doi: 10.1007/s00128-015-1726-y. Epub 2016 Jan 7. PubMed PMID: 26744022.

Dose Conversion

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In vivo Formulation Calculator (Clear solution)

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dibenz[a,h]anthracene 53-70-3 DNA Damage/DNA Repair DNA DB(a,h)A CCRIS 208 Inhibitor inhibitor inhibit

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