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L82
L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
Catalog No. T60753Cas No. 329227-30-7
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L82
Catalog No. T60753Cas No. 329227-30-7
L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $64 | In Stock | |
| 10 mg | $105 | In Stock | |
| 25 mg | $197 | In Stock | |
| 50 mg | $313 | In Stock | |
| 100 mg | $497 | In Stock | |
| 500 mg | $1,080 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $70 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells. |
| Targets&IC50 | DNA ligase I:12 μM |
| In vitro | L82 (0-50 μM; 6 d) reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa, and HCT116 in a concentration-dependent manner.[2] L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells.[2]' Revised: L82 (0-50 μM; 6 d) concentration-dependently reduced proliferation in the normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa, and HCT116, while L82 (50 μM; 0-48 h) exhibited cytostatic activity through activation of the G1/S checkpoint in MCF7 cells.[2] |
| Molecular Weight | 309.67 |
| Formula | C11H8ClN5O4 |
| Cas No. | 329227-30-7 |
| Storage | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 6 mg/mL (19.38 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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