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NSC16168

Name: NSC16168
Brand: TargetMol
SKU: T16351
Price: 423 EUR
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16351Cas No. 6837-93-0

Alias NSC 16168

NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.

NSC16168

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Purity: 99.88%

Catalog No. T16351Alias NSC 16168Cas No. 6837-93-0

NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.

Pack Size	Price	Availability
5 mg	423 €	In Stock
25 mg	1.358 €	In Stock
50 mg	1.767 €	In Stock
100 mg	2.375 €	In Stock

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Purity:99.88%

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COA HNMR HPLC LCMS

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Product Introduction

Bioactivity

Description	NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.
Targets&IC50	ERCC1 XPF:0.42 μM
In vitro	NSC16168 is a specific inhibitor of ERCC1-XPF with an IC50 of 0.42 μM. NSC16168 potentiates the antitumor effect of cisplatin on cancer cells in the concentration range of 0-50 μM. [1]
In vivo	In the H460 lung cancer xenograft model, NSC16168 was injected intraperitoneally twice a day at a dose of 20 mg/kg and showed significant antitumor effects and synergistically enhanced the efficacy of cisplatin. [1]
Alias	NSC 16168

Chemical Properties

Molecular Weight	473.5
Formula	C₁₇H₁₅NO₉S₃
Cas No.	6837-93-0
Smiles	O=S(=O)(O)C=1C=C(OS(=O)(=O)C2=CC=C(C=C2)C)C3=C(N)C=C(C=C3C1)S(=O)(=O)O
Relative Density.	1.5197 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 20 mg/mL (42.24 mM), Sonication is recommended

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1119 mL	10.5597 mL	21.1193 mL	105.5966 mL
5 mM	0.4224 mL	2.1119 mL	4.2239 mL	21.1193 mL
10 mM	0.2112 mL	1.0560 mL	2.1119 mL	10.5597 mL
20 mM	0.1056 mL	0.5280 mL	1.0560 mL	5.2798 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc