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Dimethyl sulfoxide

Catalog No. T0341 CAS 67-68-5

Synonyms: Methyl Sulfoxide, DMSO

Dimethyl sulfoxide (DMSO) is a commonly used solvent to dissolve polar and non-polar compounds. Dimethyl sulfoxide has been widely used for masterbatch preparation of compounds in biological experiments. Dimethyl sulfoxide has bacteriostatic activity.

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Dimethyl sulfoxide, CAS 67-68-5

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100 mL	In stock	$ 45.00
200 mL	In stock	$ 68.00
500 mL	In stock	$ 127.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dimethyl sulfoxide (DMSO) is a commonly used solvent to dissolve polar and non-polar compounds. Dimethyl sulfoxide has been widely used for masterbatch preparation of compounds in biological experiments. Dimethyl sulfoxide has bacteriostatic activity.
In vitro	METHODS: Human colorectal cancer cells HCT-116 and SW-480 were treated with Dimethyl sulfoxide (0.1%-1.5%) for 24 h, and cell viability was measured by MTT. RESULTS: Dimethyl sulfoxide showed a dose-dependent effect on cell proliferation. Cells treated with 1.5% Dimethyl sulfoxide showed about 10% reduction in cell growth. [1]
In vivo	METHODS: To detect toxicity, Dimethyl sulfoxide (10%-100%) was administered to Swiss mice by single intraperitoneal injection for five days. RESULTS: The LD50 increased with decreasing concentration and the LD50 values for 10%, 25%, 50%, 75%, and 100% Dimethyl sulfoxide were >10.1, 15.4, 13.3, 11.9, and 10.9 g/kg, respectively. [2]

Synonyms	Methyl Sulfoxide, DMSO
Molecular Weight	78.13
Formula	C2H6OS
CAS No.	67-68-5

Storage

-20°C for 2 years, 4°C for 1 year

References and Literature

1. Tunçer S, et al. Low dose dimethyl sulfoxide driven gross molecular changes have the potential to interfere with various cellular processes. Sci Rep. 2018 Oct 4;8(1):14828. 2. Worthley EG, et al. The toxicity of four concentrations of DMSO. Toxicol Appl Pharmacol. 1969 Sep;15(2):275-81.

Citations

1. Liang C, Yu X, Xiong N, et al. Pictilisib Enhances the Antitumor Effect of Doxorubicin and Prevents Tumor-Mediated Bone Destruction by Blockade of PI3K/AKT Pathway. Frontiers in oncology. 2020, 10. 2. Guo L, Wu Z. FOXM1‐mediated NUF2 expression confers temozolomide resistance to human glioma cells by regulating autophagy via the PI3K/AKT/mTOR signaling pathway. Neuropathology. 2022 3. Yu Z, Niu P, Su Z, et al.Role of Atractylenolide I in Cerebral Ischemia Reperfusion Injury.Revista Brasileira de Farmacognosia.2023: 1-10. 4. Chen L, Ye T, Wang X, et al.Decoction on Major Depressive Disorder based on Network Pharmacology and Molecular Docking.Combinatorial Chemistry & High Throughput Screening.2023, 26(9): 1701-1728.

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Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dimethyl sulfoxide 67-68-5 Microbiology/Virology Others Antibacterial solvent Methyl Sulfoxide bacteriostatic Bacterial Inhibitor DMSO inhibit anti-freezing anti-inflammatory aprotic inhibitor

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