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Dupilumab

Catalog No. T13666   CAS 1190264-60-8
Synonyms: REGN-668, SAR-231893

Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody against the alpha subunit of the interleukin-4 receptor, which inhibits downstream signaling of IL-4 and IL-13 and has been shown to improve atopic dermatitis.

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Dupilumab Chemical Structure
Dupilumab, CAS 1190264-60-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 239.00
5 mg In stock $ 589.00
10 mg In stock $ 858.00
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Purity: 95.00%
Purity: >99.2%
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Biological Description
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Storage & Solubility Information
Description Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody against the alpha subunit of the interleukin-4 receptor, which inhibits downstream signaling of IL-4 and IL-13 and has been shown to improve atopic dermatitis.
In vitro Dupilumab inhibited mRNA expression of T cells, dc, eosinophils, inflammatory pathways and Th2-induced chemokine activation related genes in skin lesions, and showed no activity against IL-17A and significantly decreased IL-22 levels, but 300 mg Dupilumab significantly decreased the expression of IL-17-related genes. Such as elafin (PI3), IL23p19/IL23A and S100A8, and have inhibitory potential (CXCL1 and S100A7). Dupilumab (300 mg) inhibited hyperproliferation-related genes, such as K16, and decreased the expression of S100A, as measured by microarray and qRT-PCR.[1]
In vivo In human whole blood, dupilumab inhibits IL-4 and il-13 to stimulate thymus secretion and activates chemokine/chemokine C motif ligand 17 (TARC/CCL17). (Clinical biomarker for atopic dermatitis) with yarnamore potency (50% inhibition at 0.24 to 0.52 nM and 0.26 to 0.27 nM).[1]
Synonyms REGN-668, SAR-231893
Molecular Weight N/A
CAS No. 1190264-60-8

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TargetMolReferences and Literature

1. Hamilton JD, et al. Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 2014 Dec;134(6):1293-1300. 2. Griffin R. Lee, et al. Atopic Dermatitis : Inside Out Or Outside in 2023, Pages 237-251 3. Mark Boguniewicz, et al.44 - Atopic and Contact Dermatitis.Clinical Immunology (Fifth Edition) Principles and Practice 2019, Pages 611-624. 4. Takuya Miyano, et al.A mathematical model to identify optimal combinations of drug targets for dupilumab poor responders in atopic dermatitis.Posted February 10, 2021.

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Keywords

Dupilumab 1190264-60-8 Immunology/Inflammation IL Receptor REGN 668 SAR 231893 REGN-668 SAR-231893 SAR231893 REGN668 inhibitor inhibit

 

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