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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | Inquiry | 8-10 weeks | |
50 mg | Inquiry | 8-10 weeks | |
100 mg | Inquiry | 8-10 weeks |
Description | EHNA hydrochloride is a chemical compound recognized for its antiviral, antitumor, and antiarrhythmic properties. It functions as a potent and selective inhibitor of both cyclic nucleotide phosphodiesterase 2 (PDE2) with an IC50 of 4 μM and adenosine deaminase (ADA). Additionally, it effectively inhibits the activity of cGMP-stimulated PDE II (cGs-PDE) with IC50 values of 0.8 μM in humans and 2 μM in porcine myocardium, although its inhibitory effects on unstimulated PDE2 activity are less pronounced. |
Targets&IC50 | PDE2A (human):0.8 μM |
In vitro | EHNA demonstrates Michaelian inhibition kinetics towards cyclic GMP-stimulated PDE2 activity, as evidenced by Hill plots approaching unity. It inhibits the degradation of dAdo, elevating mitochondrial dATP levels in fibroblasts. Furthermore, EHNA entirely eradicates cyclic GMP's capacity to activate PDE2 activity, though its inhibitory impact on basal PDE2 activity is significantly lesser. |
Molecular Weight | 313.83 |
Formula | C14H24ClN5O |
Cas No. | 58337-38-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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