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FK706
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory effect.
Catalog No. T15285Cas No. 144055-55-0
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FK706
Catalog No. T15285Cas No. 144055-55-0
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory effect.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,530 | 8-10 weeks | |
| 50 mg | $1,990 | 8-10 weeks | |
| 100 mg | $3,190 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef |
| Targets&IC50 | Neutrophil elastase (mouse):22 nM, Pancreatic elastase (porcine):100 nM, Neutrophil elastase (human):（ki）4.2 nM, Neutrophil elastase (human):83 nM |
| In vitro | FK706 effectively inhibits the hydrolysis of bovine neck ligament elastin (2 mg/mL final concentration) by human neutrophil elastase (4 μg/mL final concentration) (IC50: 230 nM) [1]. It blocks the release of inflammatory chemokines, suppresses the expression of IL-8 and MCP-1 mRNA, and inhibits NF-κB activation. FK706 may directly block human lung fibroblasts activation of NF-κB, preventing the expression of inflammatory chemokines during cigarette smoke-induced lung inflammation [2]. |
| In vivo | Subcutaneous injection of FK706 (10-100 mg/kg; 1-6 hours; male C57BL mice) significantly inhibits human neutrophil elastase (20 μg/paw)-induced paw edema in a dose-dependent manner (47% inhibition at 100 mg/kg) [1]. |
| Molecular Weight | 593.556 |
| Formula | C26H33F3N4NaO7 |
| Cas No. | 144055-55-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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