Powder: -20°C for 3 years
In solvent: -80°C for 2 years
FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 μM). FT827 binds to the USP7 catalytic domain (apparent Kd: 7.8 μM).
Description | FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 μM). FT827 binds to the USP7 catalytic domain (apparent Kd: 7.8 μM). |
Targets&IC50 | USP7:(kd)7.8 μM, USP7:(ki)4.2 μM |
In vitro | FT827 exclusively inhibits USP7 in a panel of 38 deubiquitinases (DUBs) from diverse families. FT827 features a vinyl sulfonamide moiety that covalently modifies the catalytic Cys223 of USP7. FT827 inhibits USP7 probe reactivity (IC50s: 0.1-2 μM), confirming 10 to 100-fold higher potency as compared to P22077 in crude cell extracts or with intact MCF7 breast cancer cells. Followed by incubation with the ubiquitin active site suicide probe haemagglutinin (HA)-tagged ubiquitin bromomethyl (HA-UbC2Br). |
Molecular Weight | 548.61 |
Formula | C27H28N6O5S |
CAS No. | 1959537-86-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 125 mg/mL (227.85 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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FT827 1959537-86-0 DNA损伤和修复 泛素化 细胞周期 DUB FT-827 Inhibitor inhibitor inhibit