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Fidarestat

Catalog No. T15281 CAS 136087-85-9

Synonyms: SNK 860

Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.

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Fidarestat, CAS 136087-85-9

Pack Size	Availability	Price/USD
1 mg	4-5 weeks	$ 198.00
5 mg	4-5 weeks	$ 890.00
10 mg	4-5 weeks	$ 1,580.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.
Targets&IC50	Aldose reductase:26 nM, AKR1B10:33 μM, AKR1B10 (V301L):1.8 μM
In vivo	Fidarestat (1 or 4 mg/kg. p.o., daily for 4 weeks) decreases the concentrations of sorbitol and fructose in diabetic rats [2].

Synonyms	SNK 860
Molecular Weight	279.22
Formula	C12H10FN3O4
CAS No.	136087-85-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (895.35 mM), Sonification is recommended.

References and Literature

1. Ruiz FX, et al. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. Chem Biol Interact. 2013 Feb 25;202(1-3):178-85. 2. Hotta N, et al. Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Exp Physiol. 1995 Nov;80(6):981-9.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fidarestat 136087-85-9 Endocrinology/Hormones Metabolism Reductase SNK 860 SNK-860 SNK860 inhibitor inhibit

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