Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.
Description | Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease. |
Targets&IC50 | V301L AKR1B10:1.8 μM, AKR1B10:33 μM, Aldose reductase:26 nM |
In vivo | Fidarestat (1 or 4 mg/kg. p.o., daily for 4 weeks) decreases the concentrations of sorbitol and fructose in diabetic rats [2]. |
Synonyms | SNK 860 |
Molecular Weight | 279.22 |
Formula | C12H10FN3O4 |
CAS No. | 136087-85-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 250 mg/mL (895.35 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Fidarestat 136087-85-9 代谢 内分泌与激素 Reductase SNK 860 Inhibitor inhibitor inhibit