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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $372 | 8-10 weeks | |
25 mg | $1,200 | 8-10 weeks | |
50 mg | $1,570 | 8-10 weeks | |
100 mg | $2,360 | 8-10 weeks | |
1 mL x 10 mM (in DMSO) | $456 | 8-10 weeks |
Description | Flesinoxan, a hypotensive agent, is an effective, high-affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM). |
In vivo | Flesinoxan functions as a partial agonist at postsynaptic and a full agonist at presynaptic 5-HT1A receptors. Its intravenous delivery inhibits the activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons, bearing a similar antagonistic effect on 5-HT's influence on CA3 pyramidal neurons as 8-OH-DPAT. Studies of acute brain penetration revealed that nine minutes post-intravenous administration, [3H]8-OH-DPAT achieves significantly higher brain concentrations than [3H]Flesinoxan. Both Flesinoxan and 8-OH-DPAT, when administered subcutaneously, induce dose-dependent hypothermia, with Flesinoxan's effect being notably reduced by the pre-administration of pindolol, a non-selective 5-HT1A antagonist, and methysergide, a 5-HT1/2 antagonist. Comparable levels of hypothermia are observed with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT, though Flesinoxan's peak effect transpires 30 minutes later than that of 8-OH-DPAT and diminishes more gradually. |
Molecular Weight | 415.46 |
Formula | C22H26FN3O4 |
Cas No. | 98206-10-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 31.25 mg/mL (75.22 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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