Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

GSK319347A

Catalog No. T15558Cas No. 862812-98-4

GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.

GSK319347A

GSK319347A

Purity: 98.42%
Catalog No. T15558Cas No. 862812-98-4
GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.
Pack SizePriceAvailabilityQuantity
1 mg$67In Stock
5 mg$155In Stock
10 mg$268In Stock
25 mg$563In Stock
50 mg$958In Stock
100 mg$1,280In Stock
1 mL x 10 mM (in DMSO)$358In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "GSK319347A"

Select Batch
Purity:98.42%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.
Targets&IC50
IKKε:469 nM, TBK1:93 nM, IKK2:790 nM
In vitro
GSK319347A (Compound 1) inhibits the TBK1 enzyme with an IC50 of 93 nM, demonstrating good cell potency at 72 nM. Additionally, IKK-3 Inhibitor shows excellent selectivity against cell-cycle kinases CDK2 and AurB[1]. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM[1].
Chemical Properties
Molecular Weight469.53
FormulaC22H19N3O5S2
Cas No.862812-98-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (85.19 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1298 mL10.6489 mL21.2979 mL106.4895 mL
5 mM0.4260 mL2.1298 mL4.2596 mL21.2979 mL
10 mM0.2130 mL1.0649 mL2.1298 mL10.6489 mL
20 mM0.1065 mL0.5324 mL1.0649 mL5.3245 mL
50 mM0.0426 mL0.2130 mL0.4260 mL2.1298 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy GSK319347A | purchase GSK319347A | GSK319347A cost | order GSK319347A | GSK319347A chemical structure | GSK319347A in vitro | GSK319347A formula | GSK319347A molecular weight