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Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $437 | In Stock | |
10 mg | $646 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,380 | In Stock | |
100 mg | $1,860 | In Stock | |
1 mL x 10 mM (in DMSO) | $547 | In Stock |
Description | Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP. |
Targets&IC50 | PDE5A:3.6 nM, PDE1A:9.1 μM |
In vitro | In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2]. |
In vivo | In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2]. |
Alias | UK-369003 |
Molecular Weight | 519.62 |
Formula | C23H33N7O5S |
Cas No. | 334826-98-1 |
Smiles | C(C)C1=C2C(=NN1CCOC)C(=O)N=C(N2)C3=C(OCC)N=CC(S(=O)(=O)N4CCN(CC)CC4)=C3 |
Relative Density. | 1.41 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (105.85 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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