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Gisadenafil

Gisadenafil
Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.
Catalog No. T15381Cas No. 334826-98-1
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Purity:99.06%
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Gisadenafil

Catalog No. T15381Cas No. 334826-98-1
Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.
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Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
5 mg$437In Stock
10 mg$646In Stock
25 mg$987In Stock
50 mg$1,380In Stock
100 mg$1,860In Stock
1 mL x 10 mM (in DMSO)$547In Stock
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Product Introduction

Bioactivity
Description
Gisadenafil (UK-369003), a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM, prevents the degradation of cGMP.
Targets&IC50
PDE5A:3.6 nM, PDE1A:9.1 μM
In vitro
In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2].
In vivo
In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2].
AliasUK-369003
Chemical Properties
Molecular Weight519.62
FormulaC23H33N7O5S
Cas No.334826-98-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (105.85 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9245 mL9.6224 mL19.2448 mL96.2242 mL
5 mM0.3849 mL1.9245 mL3.8490 mL19.2448 mL
10 mM0.1924 mL0.9622 mL1.9245 mL9.6224 mL
20 mM0.0962 mL0.4811 mL0.9622 mL4.8112 mL
50 mM0.0385 mL0.1924 mL0.3849 mL1.9245 mL
100 mM0.0192 mL0.0962 mL0.1924 mL0.9622 mL

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