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Hh-Ag1.5
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Purity:98.61%
Hh-Ag1.5
Catalog No. T24754Cas No. 612542-14-0
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $159 | In Stock | |
| 5 mg | $397 | In Stock | |
| 10 mg | $628 | In Stock | |
| 25 mg | $983 | In Stock | |
| 50 mg | $1,350 | In Stock | |
| 100 mg | $1,820 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $437 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons. |
| In vitro | Hh-Ag1.5 completely binds to the Smo-containing membranes with the Ki value of 0.52 nM.[2] The Smo agonist Hh-Ag1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM.[3] Hh-Ag1.5 (5 μM; 3 weeks) facilitates the dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from the non-injured liver in vitro.[4] |
| Alias | SAG-1.5, SAG1.5, SAG 1.5 |
| Molecular Weight | 526.04 |
| Formula | C28H26ClF2N3OS |
| Cas No. | 612542-14-0 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 26.30 mg/mL (50 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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