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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $159 | In Stock | |
5 mg | $397 | In Stock | |
10 mg | $628 | In Stock | |
25 mg | $983 | In Stock | |
50 mg | $1,350 | In Stock | |
100 mg | $1,820 | In Stock | |
1 mL x 10 mM (in DMSO) | $437 | In Stock |
Description | Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons. |
In vitro | Hh-Ag1.5 completely binds to the Smo-containing membranes with the Ki value of 0.52 nM.[2] The Smo agonist Hh-Ag1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM.[3] Hh-Ag1.5 (5 μM; 3 weeks) facilitates the dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from the non-injured liver in vitro.[4] |
Alias | SAG-1.5, SAG1.5, SAG 1.5 |
Molecular Weight | 526.04 |
Formula | C28H26ClF2N3OS |
Cas No. | 612542-14-0 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 26.30 mg/mL (50 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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