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BMS-833923

Catalog No. T2299Cas No. 1059734-66-5
Alias XL-139

BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).

BMS-833923

BMS-833923

Purity: 99.74%
Catalog No. T2299Alias XL-139Cas No. 1059734-66-5
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Pack SizePriceAvailabilityQuantity
5 mg$46In Stock
10 mg$74In Stock
25 mg$129In Stock
50 mg$208In Stock
100 mg$376In Stock
200 mg$553In Stock
500 mg$878In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Purity:99.74%
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Product Introduction

Bioactivity
Description
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Targets&IC50
BODIPY:21 nM
In vivo
BMS-833923 dose-dependently affected the transcription of prostate hedgehog signaling genes in vitro.BMS-833923 caused a decrease in hedgehog pathway activity, reduced cell proliferation, and induced apoptosis in esophageal adenocarcinoma cell lines via an endogenous pathway.
AliasXL-139
Chemical Properties
Molecular Weight473.57
FormulaC30H27N5O
Cas No.1059734-66-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 88 mg/mL (185.8 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1116 mL10.5581 mL21.1162 mL105.5810 mL
5 mM0.4223 mL2.1116 mL4.2232 mL21.1162 mL
10 mM0.2112 mL1.0558 mL2.1116 mL10.5581 mL
20 mM0.1056 mL0.5279 mL1.0558 mL5.2791 mL
50 mM0.0422 mL0.2112 mL0.4223 mL2.1116 mL
100 mM0.0211 mL0.1056 mL0.2112 mL1.0558 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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