Shopping Cart
- Remove All
- Your shopping cart is currently empty
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $46 | In Stock | |
10 mg | $74 | In Stock | |
25 mg | $129 | In Stock | |
50 mg | $208 | In Stock | |
100 mg | $376 | In Stock | |
200 mg | $553 | In Stock | |
500 mg | $878 | In Stock | |
1 mL x 10 mM (in DMSO) | $54 | In Stock |
Description | BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM). |
Targets&IC50 | BODIPY:21 nM |
In vivo | BMS-833923 dose-dependently affected the transcription of prostate hedgehog signaling genes in vitro.BMS-833923 caused a decrease in hedgehog pathway activity, reduced cell proliferation, and induced apoptosis in esophageal adenocarcinoma cell lines via an endogenous pathway. |
Alias | XL-139 |
Molecular Weight | 473.57 |
Formula | C30H27N5O |
Cas No. | 1059734-66-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 88 mg/mL (185.8 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.