Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 189.00 | |
25 mg | In stock | $ 388.00 | |
50 mg | In stock | $ 577.00 | |
100 mg | In stock | $ 826.00 | |
500 mg | In stock | $ 1,680.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM). |
Targets&IC50 | USP14:0.6 μM, IsoT/USP5:20 μM |
In vitro |
IU1-47 stimulates tau degradation principally via the ubiquitin-proteasome system. IU1-47 is essentially inactive on free USP14. IU1-47 (25 μM) antagonizes USP14 deubiquitinating activity and stimulates substrate degradation in vitro. IU1-47 (3 μM, 10, and 30 μM; 48 hours) obviously reduces Tau and phosphatase species Ser-202/Thr-205 levels in murine cortical primary neurons. |
Molecular Weight | 330.85 |
Formula | C19H23ClN2O |
CAS No. | 670270-31-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (50.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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IU1-47 670270-31-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB inhibit IU1 47 Deubiquitinase IU-1-47 DUBs Inhibitor IU147 inhibitor