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EOAI3402143

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Purity:98.09%

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COA HNMR HPLC

EOAI3402143

Catalog No. T11209Cas No. 1699750-95-2

EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.

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Pack Size	Price	Availability
1 mg	$61	In Stock
5 mg	$147	In Stock
10 mg	$239	In Stock
25 mg	$469	In Stock
50 mg	$755	In Stock
100 mg	$1,120	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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Product Introduction

Bioactivity

Description	EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.
In vitro	EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice[2]. Usp9x inhibition by EOAI3402143 treatment reduced 3D colony formation in PANC1 and PDX cell lines, induced rapid apoptosis in MIAPACA2 cells, and associated with reduced Mcl-1 and ITCH protein levels[2].
In vivo	EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice[3].

Chemical Properties

Molecular Weight	503.42
Formula	C25H28Cl2N4O3
Cas No.	1699750-95-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 75 mg/mL (148.98 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9864 mL	9.9321 mL	19.8641 mL	99.3206 mL
5 mM	0.3973 mL	1.9864 mL	3.9728 mL	19.8641 mL
10 mM	0.1986 mL	0.9932 mL	1.9864 mL	9.9321 mL
20 mM	0.0993 mL	0.4966 mL	0.9932 mL	4.9660 mL
50 mM	0.0397 mL	0.1986 mL	0.3973 mL	1.9864 mL
100 mM	0.0199 mL	0.0993 mL	0.1986 mL	0.9932 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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