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Iloprost
Catalog No. T15560Cas No. 78919-13-8
Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease.
Iloprost
Catalog No. T15560Cas No. 78919-13-8
Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $170 | 35 days | |
| 500 μg | $338 | 35 days | |
| 1 mg | $590 | 35 days | |
| 5 mg | $2,520 | 35 days |
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Concentration:1.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Iloprost (Ciloprost) is a stabilized synthetic analog of prostaglandin I2, an inhibitor of platelet aggregation and vasodilation, used in the study of cardiovascular disease. |
| In vitro | Iloprost is a PGI2 analog that affects the maturation and developmental competence of bovine oocytes. 0.5 μM Iloprost treatment for 22-24 hours increased the blastocyst rate and the proportion of expanded blastocysts in bovine embryos, increased the maturation rate of bovine oocytes and the rate of cumulus expansion, and increased mRNA expression of genes associated with cumulus expansion. [1] Iloprost reduces the occurrence of apoptosis in COC cells and promotes an anti-apoptotic balance in the transcription of apoptosis-related genes (BAX and BCL2). [1] |
| In vivo | 0.3 mg/kg/min Iloprost, administered intravenously by minipump for 33 days, showed significant anti-metastatic activity in a rat model of spontaneous metastatic tumors.[3] 0.2 mg/kg/day Iloprost, administered intravenously for 10 days, attenuated the effects of hyperoxia and reduced inflammation in the lungs of neonatal mice, where cyclooxygenase-2 (COX-2/PTGS2) mediated hyperoxia-induced injury.[2] |
| Molecular Weight | 360.49 |
| Formula | C22H32O4 |
| Cas No. | 78919-13-8 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (221.92 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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