store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inhibits the proliferation of HEK293 cells and pancreatic cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 58.00 | |
2 mg | 5 days | $ 82.00 | |
5 mg | In stock | $ 372.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 397.00 |
Description | JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inhibits the proliferation of HEK293 cells and pancreatic cancer cells. |
Targets&IC50 | Cell proliferation:0.3 μM (EC50, HEK293 cell) |
In vitro | JI051 (0.1-10 µM, 24 hours) significantly inhibits proliferation of HEK293 cells, exhibiting an EC50 of 0.3 μM, and induces G2/M cell-cycle arrest[1]. |
Synonyms | JI-051 |
Molecular Weight | 364.44 |
Formula | C22H24N2O3 |
CAS No. | 2234281-75-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (274.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
JI051 2234281-75-3 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase JI-051 JI 051 inhibitor inhibit