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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | In Stock | |
5 mg | $113 | In Stock | |
10 mg | $183 | In Stock | |
25 mg | $372 | In Stock | |
50 mg | $597 | In Stock | |
100 mg | $955 | In Stock | |
200 mg | $1,280 | In Stock | |
500 mg | $1,890 | In Stock | |
1 mL x 10 mM (in DMSO) | $137 | In Stock |
Description | JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210. |
In vitro | JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors[1]. |
In vivo | JKE-1674 (50?mg/kg; p.o.) could be detected in the serum of mice dosed orally with the compound[2]. |
Molecular Weight | 451.3 |
Formula | C20H20Cl2N4O4 |
Cas No. | 2421119-60-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 13 mg/mL (28.81 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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