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JW 642

JW 642
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively).
Catalog No. T15632Cas No. 1416133-89-5
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Purity:99.28%
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JW 642

Purity: 99.28%
Catalog No. T15632Cas No. 1416133-89-5

JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively).
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Pack SizePriceAvailabilityQuantity
10 mg$33In Stock
25 mg$65In Stock
50 mg$118In Stock
100 mg$221In Stock
200 mg$329In Stock
1 mL x 10 mM (in DMSO)$34In Stock
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Product Introduction

Bioactivity
Description
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively).
Targets&IC50
MAGL (rat):14 nM, MAGL (human):3.7 nM, MAGL:7.6 nM(mouse)
In vitro
MAGL inhibitor JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s: 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
Chemical Properties
Molecular Weight462.39
FormulaC21H20F6N2O3
Cas No.1416133-89-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (194.64 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1627 mL10.8134 mL21.6268 mL108.1338 mL
5 mM0.4325 mL2.1627 mL4.3254 mL21.6268 mL
10 mM0.2163 mL1.0813 mL2.1627 mL10.8134 mL
20 mM0.1081 mL0.5407 mL1.0813 mL5.4067 mL
50 mM0.0433 mL0.2163 mL0.4325 mL2.1627 mL
100 mM0.0216 mL0.1081 mL0.2163 mL1.0813 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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