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Kevetrin hydrochloride

Catalog No. T3184 CAS 66592-89-0

Synonyms: Thioureidobutyronitrile HCl, thioureido butyronitrile hydrochloride, 4-Isothioureidobutyronitrile hydrochloride

Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Kevetrin hydrochloride Chemical Structure

Kevetrin hydrochloride, CAS 66592-89-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 38.00
10 mg	In stock	$ 61.00
25 mg	In stock	$ 113.00
50 mg	In stock	$ 182.00
100 mg	In stock	$ 303.00
1 mL * 10 mM (in DMSO)	In stock	$ 60.00

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Purity: 99.93%

Purity: 99.38%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.

Synonyms	Thioureidobutyronitrile HCl, thioureido butyronitrile hydrochloride, 4-Isothioureidobutyronitrile hydrochloride
Molecular Weight	179.67
Formula	C5H10ClN3S
CAS No.	66592-89-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (278.29 mM)

References and Literature

1. Han D., Smalley K. (2015) Targeting the Cell Cycle and p53 in Combination with BRAF-Directed Therapy. In: Sullivan R. (eds) BRAF Targets in Melanoma. Cancer Drug Discovery and Development, vol 82. Springer, New York, NY

Citations

1. Han R, Liang L, Qin T, et al. Encephalomyocarditis Virus 2A Protein Inhibited Apoptosis by Interaction with Annexin A2 through JNK/c-Jun Pathway. Viruses. 2022, 14(2): 359. 2. Li J, Xiao S, Shi F, et al.Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse.Cell Death & Disease.2023, 14(11): 783.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Autophagy Compound Library Anti-Aging Compound Library Apoptosis Compound Library Pyroptosis Compound Library HIF-1 Signaling Pathway Compound Library Anti-Pancreatic Cancer Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Kevetrin hydrochloride 66592-89-0 Apoptosis Mdm2 p53 TP53 wild-type Thioureidobutyronitrile HCl preferential cytotoxic activity 4-Isothioureidobutyronitrile Inhibitor inhibit blast cells MOLM-13 thioureidobutyronitrile thioureido butyronitrile Hydrochloride thioureido butyronitrile hydrochloride Kevetrin Kevetrin Hydrochloride 4-Isothioureidobutyronitrile hydrochloride thioureido butyronitrile 4-Isothioureidobutyronitrile Hydrochloride myeloid leukemia MDM-2/p53 KASUMI-1 mutant primary inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.