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L-771688 (SNAP 6383) is a novel potent and selective α1A-adrenoceptor antagonist with a Ki value of 0.43±0.02 nM.L-771688 KE is used for the treatment of benign prostatic hyperplasia.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $700 | 6-8 weeks | |
5 mg | $1,800 | 6-8 weeks |
Description | L-771688 (SNAP 6383) is a novel potent and selective α1A-adrenoceptor antagonist with a Ki value of 0.43±0.02 nM.L-771688 KE is used for the treatment of benign prostatic hyperplasia. |
Targets&IC50 | L-771688:0.052 ± 0.008 n M (Ki), Terazosin:1.8±0.65 nM (Ki), GG818:0.026 ± 0.002 nM (Ki) |
In vitro | Highly potent inhibition of specific [3H]L-771688 binding to cloned human α1A-Adrenoceptors is observed with subtype-selective compounds GG818 (Ki=0.026±0.002 nM) and L-771688 (Ki=0.052±0.008 nM), as well as subtype non-selective α1-adrenoceptor antagonists prazosin (Ki=0.088±0.032 nM) and terazosin (Ki=1.8±0.65 nM). The relative amount of [3H]L-771688 (0.5 nM) binding in various rat tissue membranes is highest in the submaxillary gland (9.5 pmol/g tissue), followed by the brain (5.8 pmol/g tissue), vas deferens (4.3 pmol/g tissue), kidney (3.4 pmol/g tissue), heart (1.5 pmol/g tissue), urethra (1.1 pmol/g tissue), and prostate (0.88 pmol/g tissue). In contrast, low specific [3H]L-771688 binding is observed in rat urinary bladder (0.55 pmol/g tissue), liver (0.44 pmol/g tissue), aorta (0.11 pmol/g tissue), and spleen (0.11 pmol/g tissue)[1]. |
Alias | SNAP 6383 |
Molecular Weight | 557.59 |
Formula | C28H33F2N5O5 |
Cas No. | 200050-59-5 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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