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LCKLSL acetate

Catalog No. TP2482 CAS TP2482

Synonyms: LCKLSL acetate(533902-29-3 free base)

LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.

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LCKLSL acetate, CAS TP2482

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1 mg	Inquiry	$ 112.00
5 mg	Inquiry	$ 227.00
10 mg	Inquiry	$ 412.00
25 mg	Inquiry	$ 686.00
50 mg	Inquiry	$ 977.00
100 mg	Inquiry	$ 1,320.00

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Purity: 99.9%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.
In vitro	LCKLSL acetate (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions in human retinal microvascular endothelial cells (RMVECs)[1].
In vivo	In chicken chorioallantoic membrane and murine Matrigel plug assays, LCKLSL acetate significantly decreased the vascular length. LCKLSL acetate(5 μg/mL) significantly decreased the number of vascular branches, junctions and end-points[1].

Synonyms	LCKLSL acetate(533902-29-3 free base)
Molecular Weight	735.93
Formula	C32H61N7O10S
CAS No.	TP2482

Storage

store at low temperature,keep away from moisture,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (13.5 mM)

References and Literature

1. Mallika Valapala, et al. A Competitive Hexapeptide Inhibitor of Annexin A2 Prevents Hypoxia-Induced Angiogenic Events. J Cell Sci. 2011 May 1;124(Pt 9):1453-64.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Peptide Compound Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LCKLSL acetate TP2482 GPCR/G Protein Annexin A LCKLSL acetate(533902-29-3 free base) LCKLSL Acetate inhibitor inhibit

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