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LY2365109 hydrochloride

Catalog No. T11908 CAS 1779796-27-8

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.

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LY2365109 hydrochloride Chemical Structure

LY2365109 hydrochloride, CAS 1779796-27-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 538.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.47%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
Targets&IC50	GlyT1 (human):15.8 nM nM
In vivo	LY2365109 hydrochloride increases seizure thresholds in mice[2].LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine[1].?

Molecular Weight	421.91
Formula	C22H28ClNO5
CAS No.	1779796-27-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (71.11 mM)

References and Literature

1. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54. 2. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Related compounds with same targets

Bitopertin (R enantiomer) Opiranserin hydrochloride ASP2535 Sarcosine Amoxapine Org 25543 hydrochloride PF-03463275 Bitopertin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LY2365109 hydrochloride 1779796-27-8 Neuroscience GlyT neuroblastoma Glycine transporters LY2365109 Human LY2365109 Hydrochloride LY-2365109 hydrochloride LY 2365109 LY-2365109 Hydrochloride glycine seizure LY-2365109 uptake LY 2365109 Hydrochloride Inhibitor inhibit inhibitor

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