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Linsidomine hydrochloride

Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release.

Catalog No. T23356Cas No. 16142-27-1

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Purity:99.81%

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COA HPLC HNMR

Linsidomine hydrochloride

Catalog No. T23356Cas No. 16142-27-1

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Pack Size	Price	Availability
5 mg	$64	In Stock
10 mg	$97	In Stock
25 mg	$176	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock

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Product Introduction

Bioactivity

Description	Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release.
In vitro	SIN-1 decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion [1][2].
In vivo	SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits a potent vasorelaxant effect and inhibition of platelet aggregation.[1] SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.[2]
Alias	SIN-1 chloride

Chemical Properties

Molecular Weight	206.63
Formula	C₆H₁₁ClN₄O₂
Cas No.	16142-27-1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 22.5 mg/mL (108.9 mM), Sonication and heating to 60℃ are recommended.

H2O: 45.0 mg/mL (217.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.8396 mL	24.1978 mL	48.3957 mL	241.9784 mL
5 mM	0.9679 mL	4.8396 mL	9.6791 mL	48.3957 mL
10 mM	0.4840 mL	2.4198 mL	4.8396 mL	24.1978 mL
20 mM	0.2420 mL	1.2099 mL	2.4198 mL	12.0989 mL
50 mM	0.0968 mL	0.4840 mL	0.9679 mL	4.8396 mL
100 mM	0.0484 mL	0.2420 mL	0.4840 mL	2.4198 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SIN 1 ChlorideSIN-1 ChlorideSIN1 ChlorideLinsidomine Hydrochloride